Tolvaptan jynarque, samsca is a selective vasopressin. Initiate and reinitiate therapy only in a hospital where serum sodium levels can be monitored. A initiate and re initiate in a hospital and monitor serum sodium. Samsca should be initiated and reinitiated in a hospital 2.
Distributed and marketed by otsuka america pharmaceutical, inc. Removing excess water with samsca helps you manage hyponatremia while you are treating your patients primary condition. Soliris is a prescription medicine that is used to treat patients with a disease called paroxysmal nocturnal hemoglobinuria pnh. Tolvaptan samsca, jynarque independence blue cross. See full prescribing information for complete boxed warning. Risk of serious liver injury jynarque tolvaptan can cause serious and potentially fatal liver injury. Please note, product provided under bridgerx may not be sold, resold, billed, or otherwise reimbursed. Start samsca tolvaptan to increase free water clearance.
In the two doubleblind, placebocontrolled trials of patients with adpkd, hypernatremia defined as any serum sodium concentration 150 meql was observed in 4. Avoid fluid restriction during the first 24 hours of therapy. Samsca tolvaptan is indicated for the treatment of clinically important, non hypovolemic. Jynarque tolvaptan jynarque tolvaptan 2 full prescribing information warning. There is an additional boxed warning in the package insert addressing the risk of osmotic demyelination due to too rapid correction of hyponatremia e. Toorapid correction of serum sodium can cause serious neurologic sequelae. Samsca should be initiated and reinitiated in patients only in a. Titrate to 30 mg once daily, after at least 24 hours, up to a maximum of 60 mg once daily, as needed to raise serum sodium. See full safety and prescribing information, including boxed warning. Acute liver failure requiring liver transplantation has been reported see warnings and precautions 5. Carefirst bluecross blueshield is the shared business name of carefirst of maryland, inc. It provides a limited supply of samsca without charge to the patient or the patients health insurance if the otsuka patient support program anticipates a delay to dispense samsca.
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